TNK-tPA for Acute Myocardial Infarction: The Clinical Experience

Sorin V. Pislaru; Frans Van de Werf

doi:10.1055/s-0037-1615567

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1999; 82(S 01): 117-120
DOI: 10.1055/s-0037-1615567

Commentaries

Schattauer GmbH

TNK-tPA for Acute Myocardial Infarction: The Clinical Experience

Sorin V. Pislaru

¹From the Department of Cardiology, University of Leuven, Leuven, Belgium

,

Frans Van de Werf

¹From the Department of Cardiology, University of Leuven, Leuven, Belgium

› Author Affiliations

Abstract

Summary

Thrombolytic therapy has become the mainstay of treatment for acute transmural myocardial infarction. Present fibrinolytic regimens have a number of shortcomings, including the failure to induce early and sustained reperfusion in as many as 40-50% of the patients, and to prevent reocclusion in another 10-20% of the patients. The efforts for improving thrombolysis are focused on the development of new agents (fibrinolytics, anticoagulants, and antiplatelet agents). TNK-tPA is a triple combination mutant of wild-type tissue plasminogen activator that exhibits a longer plasma half-life, an enhanced fibrin-specificity, and an increased resistance to the plasminogen activator inhibitor-1. This paper summarizes the results of clinical trials with TNK-tPA in acute myocardial infarction.

Key words

Thrombolysis - TNK-tPA - acute myocardial infarction

Full Text

References

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